Mn-Ce high-content iron ash desulfurizer was prepared by hydration impregnation method and used to remove SO2 from the simulated flue gas. The role of metal components in desulfurization,and the effects of desulfurization temperature and atmosphere on the SO2 removal performance were systematically studied. The results show that Mn-Ce/5FACa has good SO2 removal performance at 300 ℃ in the simulated flue gas (5% O2,500 mg/m3 SO2,167 mg/m3 NO and N2 balance),with the breakthrough time of 241 min and sulfur capacity of 108.45 mg/g. The SO2 removal by Mn-Ce/5FACa is the result of the combined effect of adsorption removal and chemical reaction with proportion of 30% and 70%,respectively. The results of adsorption kinetics reveal that chemisorption plays a main role in the adsorption removal of SO2 by adsorption of Mn-Ce/5FACa,and the kinetics of adsorption reaction follows the quasi-second-order kinetic equation model. The addition of Mn and Ce improves the oxygen storage and redox ability of Mn-Ce/5FACa. The combined action of Mn，Ce and high-content iron ash is conducive to the formation of K2FeO4 and MnAl2O5. Fe(VI) in K2 FeO4 provides oxidation sites in the surface of Mn-Ce/5FACa and promotes the oxidation reaction of SO2. The chemisorption is mainly affected by the desulfurization tempera[JP2]ture,and the desulfurization capacity of Mn-Ce/5FACa for SO2 increases firstly and then decreases with the increasing temperature. O2 plays a key role in the chemical reaction desulfurization,and the oxidation ability of K2 FeO4 is affected by the content of O2. NO may promote the chemical reaction between Mn-Ce/5FACa and SO2,and the desulfurization ability increases with the increase of NO concentration.