Based on the actual coal chemical system, the research on the coupling technology of coal gasification chemical industry, solid oxide fuel cell and gas turbine is a new idea to accelerate the engineering and commercial development of IGFC. The Inner Mongolia Rongxin Chemical multi-nozzle opposed coal water slurry gasification and methanol production system of Shandong Energy Group Co., Ltd. was designed to carry out the construction of coal gasification chemical engineering, solid oxide fuel cell, and turbine process flows by Aspen Plus, a chemical process analysis software. The effects of operating parameters on the integrated coal gasification fuel cell power generation and methanol co-generation (IGFC-PMC) system were studied by simulation calculation, and the chemical output, power and thermal output of the system under typical conditions were analyzed. On this basis, the influences of key parameters of gasifier on output, efficiency and other operating parameters of key components were analyzed. The results show that the methanol production unit combined with fuel cells can improve the overall efficiency of the system from 57.71% to 59.22%, indicating that the new system has advantages in energy utilization efficiency. When the concentration of coal water slurry increases from 55% to 60%, there is the greatest influence on the power and efficiency of fuel cells and little improvement on the overall efficiency. The efficiency of fuel cell increases from 42.46% to 68.42%, the power increases from 2.65 MW to 4.22 MW, and the power of turbine 1st increases from 6.23 MW to 6.56 MW. When the proportion of pumping gas increases from 0 to 51.59%, the impact on methanol production is small because the pumping volume is less than 2% relative to the total amount of syngas. In addition, the overall efficiency increases from 59.20% to 60.70%. It is feasible to adjust the supply of "chemicals, heat and electricity" by extracting part of the purified gas. It is suggested to expand the generator set by setting parallel standby units, so as to reduce the difficulty of operation regulation and maintain the high efficiency of fuel cells. The optimized design of the original methanol production system not only improves the overall energy efficiency of the system, but also realizes the transformation from a single output chemical and waste heat to the combined supply of chemical, heat and electricity, providing a new idea for chemical system to relieve the pressure of production electricity and product diversity and economic optimization.