The desulfurization wastewater produced by wet desulfurization in thermal power plants is difficult to treat, and the flue evaporation technology of desulfurization wastewater can effectively reduce the discharge of desulfurization wastewater and even achieve zero emission of desulfurization wastewater, thereby reducing the operation cost of power plants. In order to guide the practical application of flue evaporation technology of desulfurization wastewater, the heat and mass transfer model of atomized droplets in the flue gas was established to reveal the process of spray evaporation of desulfurized wastewater in the tail flue of the boiler. Taking the tail flue of a 330 MW boiler as the research object, the effects of flue gas and atomized droplet properties on the evaporation process of wastewater were studied with multiple nozzles by CFD simulation. The results show that when the number of nozzles is properly increased at a certain flow rate, the less the wastewater flow of a single nozzle, the more uniform the distribution of wastewater droplets in the flue,and the area of the low-temperature area above the nozzle gradually increases along the flow direction, the average temperature and minimum temperature increase.With different flue gas and droplet properties, the increase of the number of nozzles will make the evaporation speed of droplets faster, and the evaporation time and moving distance will be shortened, but the shortening range will gradually decrease, and the evaporation distance of droplets is positively related to the evaporation time. The number of nozzles has little effect on the droplet velocity, and the droplet velocity is hardly affected by the change of the number of nozzles, but the droplet velocity is mainly affected by the flue gas velocity. With different nozzle numbers, droplet evaporation time and distance decrease with rising of flue gas temperature, droplet jet velocity, droplet initial temperature and reducing of water vapor content, droplet initial diameter. The increase of the flue gas flow rate reduces the evaporation time. In the case of single nozzle, the evaporation distance first decreases and then increases. When the flue gas flow rate is 10 m/s, the minimum evaporation distance is 9.85 m. In the case of multiple nozzles, the evaporation distance is always reduced.