In recent years,accidents occur frequently in VOCs treatment installations and processes,resulting from the fact that there is not developed safety assessment methodology available for design,construction,and operation of VOCs purification projects. The intrinsic characteristics of VOCs treatment projects was discussed,a survey of theory,method and tools for safety assessment of chemical processes was conducted,the similarities and differences between VOCs treatment projects and chemical processes were figured out. On this basis,combined with the characteristics of VOCs treatment engineering,the chemical safety evaluation method is selected and revised. A VOCs treatment engineering safety evaluation system of integrating safety check list (SCL),hazard and operability study (HAZOP),risk matrix,layer of protection analysis (LOPA),fault tree analysis (FTA) and shock wave overpressure calculation is preliminarily constructed,and the information sharing mode is determined. The initial event frequency and consequence severity obtained from HAZOP analysis can be used as the data source of risk matrix analysis,and the assessment of accident risk level by risk matrix can figure out more serious accidents for further LOPA analysis. Besides,the initial events identified by HAZOP can also provide accident events for FTA analysis. This safety assessment methodology is targeted for VOCs treatment project,combines several safety assessment methods closely and efficiently share data among methods,and the assessment process is systematic,efficient and hierarchy.