Lithium, gallium and other strategic key metals are endowed in the coal gangue in some mining areas of Shanxi and Inner Mongolia, and the enrichment of lithium and gallium elements has gradually become a research hotspot. However, the content of lithiumand gallium in coal gangue is very low, and direct leaching needs to consume a lot of chemicals, so it is still a big challenge to enrich lithium and gallium efficiently and economically. In order to improve the enrichment efficiency of lithium and gallium in the coal gangue, research was carried out on the state of lithium and gallium in the coal gangue in Shuozhou, Shanxi Province, and the pre-enrichment method. Using step-by-step chemical extraction method, mineral phase composition, mineral dissociation analysis, inductively coupled plasma mass spectrometry, scanning electron microscopy and energy dispersive spectroscopy, the Li and Ga elements in the coal gangue werestudied, and the feasibility of the pre-enrichment of Li and Ga in the coal gangue by removing pyrite was investigated by using high-gradient magnetic separation. The results show that the gangue is mainly composed of kaolin, pyrite, quartz, calcite, mica and other minerals,and the elements of lithium and gallium are mainly in silicate minerals, with less pyrite content. The lithium content in the original ore is146.37 μg/ g, and gallium content is 25.04 μg/ g. Lithium and gallium elements can be pre-enriched in the gangue through pyrite threwoff by magnetic separation. In 1 000 mT, pre-enrichment effect is the best, and the lithium in the magnetically selected tailings is210.63 μg/ g which is 1.45 times of lithium content, the lithium recovery rate is 88.00%. Gallium recovery rate is 31.88 μg/ g which ishigher than the gallium element in the original ore, and gallium recovery rate is 80.07%.