efficient use of medium and low temperature coal tar can promote the clean and efficient conversion of coal resources. The removal of oxygen atoms from medium and low temperature coal tar is achieved by catalytic hydrodeoxygenation, which improves the hydrogen/ carbon ratio and stability of the oil to obtain a high-quality fuel. Dibenzofuran was characterized by its high content and low reactivity, whichwas chosen as a model compound for the hydrodeoxygenation reaction study in this study. Modulation of Strong Metal-Support Interactions(SMSI) is widely used in heterogeneous catalysis field, but its effect on the hydrodeoxygenation is unclear. To investigate the effect of SMSI on the hydrodeoxygenation, nickel-titanium-zirconium layered double hydroxides were used as catalyst precursors, and Ni-based catalysts (denoted as Ni/ mZrO@ TiO, m = 0- 0.5) with different SMSI were prepared for the hydrodeoxygenation reaction of the coaltar model compound dibenzofuran by varying the Zr ratio. Characterization by HRTEM, H-TPD and CO-pulse show that after high temperature calcination of the precursors, during the reduction process, part of the support is reduced to TiO to form an encapsulation layeron the surface of the Ni particles, and oxygen vacancies are simultaneously generated. As the Zr ratio increases, the SMSI strength decreases, resulting in a decrease in the encapsulation and oxygen vacancy content. The activity of the catalysts with different SMSI strengths wasevaluated and it was found that the yield of the deoxygenated product increased from 60.7% to 94.8% and then decreased to 66.9% withdecreasing SMSI strength (increasing Zr ratio) at 280 ℃ and 6 MPa. The Ni/ 0.4ZrO@ TiO catalyst exhibites the highest deoxygenationperformance, which show no decrease in activity after 5 cycles, indicating good stability. The results show that the hydrodeoxygenation performance of the catalyst is determined by the combination of encapsulation and oxygen vacancy vacancies by SMSI on the catalyst, with thedegree of Ni encapsulation negatively correlated with the hydrogenation performance and the oxygen vacancy content positively correlatedwith the deoxygenation performance.