Abstract: In China' s current energy structure,the proportion of fossil energy,especially coal resources,is relatively high,which causes great environmental pressure. As a solid waste with rapidly increasing yield in recent years,antibiotic filter residue is also a kind of biomass fuel resource,but research on the energy utilization of residue is insufficient at present. In this paper,CH_4 and other gases were used to simulate the combustible components of the residue,and the PFR reactor in Chemkin software was used to construct the model of oxygen staged combustion and unstaged combustion of residue in O_2/CO_2 atmosphere. NO_x production characteristics under the two conditions were simulated to study the influences of various factors in oxygen staged combustion and unstaged combustion,and the reaction mechanism of the results were analyzed by production rate analysis and sensitivity analysis. The results show that under the oxygen unstaged combustion,the conversion rate of NO_x first increases and then decreases with the increase of combustion temperature,reaching the peak at about 1 500 ℃; the conversion rate of NO_x increases with the increase of excess air coefficient,and increases significantly when the excess oxygen coefficient increases from 0.9 to 1.1. Under the oxygen staged combustion,the combustion temperature of primary combustion area has a complicated effect on the conversion rate of NO_x; the conversion rate of NO_x first decreases and then increases with the increase of rate of overfire air; the conversion rate of NO_x decreases as the position of over fire air is pushed back. Under the oxygen staged combustion,the reducing atmosphere promotes the transformation of N in NO_x to other components,which can significantly reduce the NO_x production. The NO_x conversion rate is the lowest when the combustion temperature is lower than 1 500 ℃ and the rate of overfire air is about 0.35. In this paper,the reaction kinetics simulation study of the combustion of antibiotic filter residue in O_2/CO_2 atmosphere is carried out for the first time,and the influences of various factors is explored,which has a guiding significance for the energy utilization of residue.