Abstract: Efficient catalyst preparation is crucial for enhancing the activity of CO2 hydrogenation to methanol, facilitating the utilization of CO2 resources. In this study, four copper-based catalysts supported by zirconium bimetallic oxides, namely Cu/Ti1Zr4O2, Cu/Zn1Zr4O2, Cu/Ga1Zr4O2, and Cu/Ce1Zr4O2, were synthesized and tested in CO2 hydrogenation experiments for methanol production. The results showed that the Cu/Ti1Zr4O2 catalysts with Ti1Zr4O2 oxides as carriers had good catalytic activity. Characterization analyses showed that the H2 reduced Cu/Ti1Zr4O2 catalysts had a large number of unsaturated Cu species (Cu0) on the surface, which combined with abundant oxygen vacancies and surface alkaline sites to promote the adsorption and activation of CO2 and H2. The smaller Cu particle size, larger Cu specific surface area and dispersion combined to promote H2 activation. The excellent physicochemical properties enabled the Cu/Ti1Zr4O2 catalyst to exhibit good catalytic activity. In addition the reaction mechanism suggests that formate species are key intermediates in the synthesis of methanol from CO2 hydrogenation catalyzed by Cu/Ti1Zr4O2 catalysts.