Abstract: As a crucial “backstop” technology for mitigating climate change, direct air capture (DAC) has garnered increasing attention from both academia and industry. However, the large-scale deployment of DAC technology depends on breakthroughs in laboratory-scale processes. At the laboratory scale, DAC adsorbents are typically synthesized in powder form and packed into reaction beds for gas separation testing. However, for industrial-scale applications, as equipment size increases, converting powdered adsorbents into monolithic structures enables better control over flow dynamics, heat transfer, and mass transfer, thereby improving overall energy efficiency. Therefore, the development of monolithic adsorbents is essential for translating laboratory research into practical engineering applications. This review summarizes recent advances in large-scale fabrication techniques for DAC adsorbents. First, the primary shaping methods for adsorbents along with their typical steps and characteristics are introduced. Next, the adsorption performance of different monolithic adsorbents is compared. Finally, key considerations in large-scale manufacturing, equipment development, and the evaluation metrics for monolithic adsorbents are discussed.