Abstract: Through analysis and comparison of two denitrification schemes, SCR and SNCR+SCR, for newly-built CFB boilers, indicate that both the SCR scheme and SNCR+SCR scheme meet the requirements for the use of newly-built CFB boilers. SCR denitrification technology is mature, the system is simple, the denitrification efficiency is high, there are few moving equipment and low failure rate, and it is widely used. The SNCR+SCR scheme requires fewer catalysts compared to the SCR scheme, and the cost of disposing of waste catalysts in the later stage is low; The system resistance is 180 Pa, and the oxidation rate of SO₂/SO₃ is lower than that of the SCR scheme. The tail flue has less ash accumulation and blockage, and the probability of corrosion of the air preheater is lower. The investment cost of SNCR+SCR scheme is 2.1 million yuan higher than that of SCR scheme, and the operating cost is 613000 yuan/year higher than that of SCR scheme. Compared with other indicators such as investment, operation and maintenance costs, denitrification efficiency, and ammonia escape, the SCR scheme is more optimal for the CFB boiler in the new project, with a 2+1 catalyst layout. Considering that the high amount of mixed combustion of activated sludge and chemical sludge in this project will lead to an increase in fly ash content, which is not conducive to the operation of SCR catalysts, SNCR ammonia injection ports will be reserved during boiler design and manufacturing.