Abstract: To address air pollution caused by municipal solid waste incineration and to explore new pathways for resource utilization, a technical route for efficient methanol production through the integration of municipal solid waste plasma gasification and catalytic reforming of coke oven gas is proposed. The environmental burden associated with conventional incineration is thereby reduced. In this route, municipal solid waste is rapidly pyrolyzed and gasified by plasma gasification technology to generate syngas rich in carbon monoxide and hydrogen. Coke oven gas is then introduced as a supplementary feedstock, and the syngas composition is optimized through catalytic reforming, so that the methanol synthesis yield is improved. A full-process simulation model, including plasma gasification, catalytic reforming, syngas purification and methanol synthesis, is established using Aspen Plus. The proposed route is compared with a methanol production route in which the syngas composition is adjusted by the water-gas shift reaction. The simulation results show that the methanol synthesis yield and energy utilization efficiency of the new system are 90.57% and 61.28%, respectively, which are increased by 1.07% and 6.19% compared with those of the water-gas shift route. The exergy efficiency of the system reaches 63.74%, indicating the rationality and high efficiency of energy utilization. The economic assessment shows that the system achieves an annual municipal solid waste treatment capacity of 74.91 t, an annual coke oven gas treatment capacity of 7 734.76 t, and an annual methanol production capacity of 16 270.55 t. The dynamic payback period is 5.18 years, and the net present value reaches 156.011 8 million CNY. In terms of environmental benefits, the CO₂ emission per tonne of methanol produced by the system is lower than 0.06 t, which is far below the value of 0.72 t for the methanol production route based on syngas adjustment through the water-gas shift reaction. Therefore, efficient resource utilization of municipal solid waste and low-carbon methanol production are achieved, while the conversion of waste into high-value chemicals is promoted. Significant advantages are demonstrated in thermodynamic performance as well as economic and environmental benefits.